Jump to content
AA NEWS UPDATE
  • ADVERTISE ON AA FORUMS WITH A UNIQUE EXPERIENCE
  • ADS PACKAGES ARE NOW AVAILABLE IN STORE >>> CLICK HERE
  • READ OUR DETAILED ADVERTISEMENT GUIDE FOR ADS SPACES - CLICK HERE
  • PARTICIPATE IN THE *POWEROIDS MOTIVATION CONTEST* >>> CLICK HERE
Mountain-Man

Delta sleep inducing peptide

Recommended Posts

Mountain-Man
3 pm#5617EDIT | CLOSE | STICK (TO FRONT) | MERGE | TRASH | SPAM | REPLY | QUOTE
 

Delta sleep-inducing peptide, abbreviated DSIP, was first discovered in 1974 by the Swiss Schoenenberger-Monnier group who isolated it from the cerebral venous blood of rabbits in an induced state of sleep. It was primarily believed to be involved in sleep regulation due to its apparent ability to induce slow-wave sleep.

* Decreases basal corticotropin level and blocks its release.
* Stimulates release of luteinizing hormone.
* Stimulates release of somatoliberin and somatotrophin secretion and inhibits somatostatin secretion.

Roles in physiological processes:

* Can act as a stress limiting factor.
* May have a direct or indirect effect on body temperature and alleviating hypothermia.
* Can normalize blood pressure and myocardial contraction.
* It has been shown to enhance the efficiency of oxidative phosphorylation in rat mitochondria in vitro, suggesting it may have antioxidant effects.

There is also conflicting evidence as to its involvement in sleep patterns. Some studies suggest a link between DSIP and slow-wave sleep (SWS) promotion. It has been found to have anticarcinogenic properties. In a study on mice, injecting a preparation of DSIP over the mice’s lifetime decreased total spontaneous tumor incidence 2.6-fold. The same study found it to also have geroprotective effects: it slowed down the age-related switching-off of oestrous function; it decreased by 22.6% the frequency of chromosome aberrations in bone marrow cells and it increased by 24.1% maximum life span in comparison with the control group.

Levels of DSIP may be significant in patients diagnosed with major depressive disorder (MDD). In several studies, levels of DSIP in the plasma and cerebrospinal fluid are significantly deviated from the norm in patients with MDD, though there are contradictions as to whether levels are higher or lower than healthy control patients. Studies have shown that administration of DSIP can alleviate narcolepsy and normalize disturbed sleeping patterns.

Edited by Mountain-Man
  • Like 1

Share this post


Link to post
Share on other sites
Mountain-Man
4 minutes ago, musclememory said:

Been looking into this myself lately. Any personal experience with it yourself?

Not yet but I have some on the way for a trial run

  • Like 1

Share this post


Link to post
Share on other sites
MBTJR1980

Good read MM! I would love a drug that could help me fall asleep at night without grogginess next day or addictive properities such as benzodiazepines like zanax, ativan, and k-pins. Ambien works good but leaves in a fog next day dragging ass. I have terrible night time anxiety so i have to use meds to get myself down for the night. If there was another way id be all in 

  • Like 2

IJL Representative

Email: [email protected]

Share this post


Link to post
Share on other sites
musclememory
39 minutes ago, Mountain-Man said:

Not yet but I have some on the way for a trial run

Sweet keep us all posted please brother

  • Like 2

Share this post


Link to post
Share on other sites
BigJH
On 1/29/2019 at 6:30 PM, MBTJR1980 said:

Good read MM! I would love a drug that could help me fall asleep at night without grogginess next day or addictive properities such as benzodiazepines like zanax, ativan, and k-pins. Ambien works good but leaves in a fog next day dragging ass. I have terrible night time anxiety so i have to use meds to get myself down for the night. If there was another way id be all in 

Me to brother. I got the same shit. Its damn right awful for me some nights. And sometimes 3 ,4 days a week..

  • Like 1

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now

×
×
  • Create New...